Xiaogai Yang： Ph.D., Professor-->

Tel: +86-10-82801539

E-mail: yxg@bjmu.edu.cn

Address: Department of Chemical Biology, --> School of Pharmaceutical Sciences, Peking University , Beijing 100191, China

Education

Beijing Medical University                    Chemistry                                                 B.S., 1992

Beijing Medical University                    Inorganic Chemistry                                  M.S., 1995

Peking University                                 Medicinal Chemistry                                  Ph.D., 2002

Professional Background

2010-present      Professor, Department of Chemical Biology, Peking University , Beijing

2004-2010         Associate Professor, Department of Chemical Biology, Peking University , Beijing

2004-2005          Visiting scientist, Leiden-Amsterdam Center for Drug Research, Leiden University , Netherland

1998-2004         Assistant professor, School of Pharmaceutical Sciences , Peking University , Beijing

1995-1998      Teaching Assistant, School of Pharmaceutical Sciences, Beijing Medical University , Beijing

Teaching

Teaching courses: Cellular inorganic chemistry; Bioinorganic chemistry

Research Interests

Current research interests involve the cellular inorganic chemistry and medicinal inorganic chemistry and mainly focus on:(1) Investigating the chemical and biochemical rules governing the cellular responses to metal ion and metal-based compounds;(2) Elucidating the roles of metal-based compounds in various cellular biological processes.

The specific goals in the current projects are：

¨ To clarify the molecular mechanisms underlying cell proliferation by lanthanides

¨ Molecular mechanisms of vanadium complexes as antidiabetic and antitumor agents

Honor and Awards

Honors and Awards: 2008 Young Investigator Award (1^st group of awards for young investigators in Peking University Health Science Center ); 2007, 2003 Teaching Award, Peking University

Representative Publications 

1.       Jin-Xia Li, Li-Juan Fu, Xiao-Gai Yang*，Kui Wang, Integrin-mediated signaling contributes to gadolinium-containing particles -promoted cell survival and G1 to S phase cell cycle transition by enhancing focal adhesion formation, J. Biol Inorg Chem, 2011, online.

2.       Tong-Tong Liu, Yan-Jun Liu, Qin Wang, Xiao-Gai Yang*, Kui Wang, Reactive-oxygen-species-mediated Cdc 25C degradation results in differential antiproliferative activities of vanadate, tungstate, and molybdate in the PC-3 human prostate cancer cell line, J. Biol Inorg Chem, 2011, online.

3.       Qin Wang, Tong-Tong Liu, Ying Fu, Kui Wang, Xiao-Gai Yang*，Vanadium compounds discriminate hepatoma and normal hepatic cells by differential regulation of reactive oxygen species，J. Biol Inorg Chem, 2010, 15:1087–1097.

4.       Jin-Xia Li, Jing-Cheng Liu, Kui Wang , Xiao-Gai Yang*，Gadolinium-containing bioparticles as an active entity to promote cell cycle progression in mouse embryo fibroblast NIH3T3 cells, J. Biol Inorg Chem, 2010(15):547–557.

5.       Lan Yuan, Ping Du, Kui Wang, Xiao-Gai Yang*，Uptake of Diterbium Transferrin, a Potential Multi-photon Excited Microscopy Probe, into Human Leukemia K562 Cells via Transferrin Receptor-mediated Process，J. Biol Inorg Chem 2009(14):1243-1251.

6.       Ying Zhang, Li-Juan Fu, Jin-Xia Li, Xiao-Gai Yang*, Xiao-Da Yang, Kui Wang. Gadolinium promoted proliferation and enhanced survival in human cervical carcinoma cells，Biometals, 2009,22(3): 511-519.

7.       Li-Juan Fu, Jin-Xia Li, Xiao-Gai Yang*, Kui Wang*, Gadolinium Promoted Cell Cycle Progression with Enhanced S-phase Entry via Activation of Both ERK and PI3K Signaling Pathways in NIH 3T3 cells, J Biol Inorg Chem 2009,14(2):219-227.

8.       Ying Fu, Qin Wang, Xiao-Gai Yang*, Xiao-Da Yang, Kui Wang., Vanadyl bisacetylacetonate induced G1/S cell cycle arrest via high intensity ERK phosphorylation in HepG2 cells, J Biol Inorg Chem 2008, 13, 1001–1009.

9.       Xiao-Gai Yang, Xiao-Da Yang, Lan Yuan, Kui Wang, DC Crans, The permeability and cytotoxicity of insulin-mimetic vanadium compounds, Pharm. Res. 2004, 21(6), 1026-1033.

10.   Xiaogai Yang, Kui Wang, Jingfen Lu, DC Crans, Membrane transport of vanadium compounds and the interaction with the erythrocyte membrane, Coord. Chem. Rev 2003, 237, 103-111.