Runtao Li   Professor  

Chemical Biology and Medicinal Chemistry

Phone:   010-82801504

Fax:     010-82716956   

Email:   lirt@mail.bjmu.edu.cn

Education:

B.Sc.  Zhengzhou University, 1981.12;

M.Sc.  Zhengzhou University, 1988.6;

Ph.D.  Dalian University of Technology, 1993.6;

Experiences

2000 ~          Professor, School of Pharmaceutical Sciences, Peking University;

1996~2000       Associate professor, School of Pharmaceutical Sciences, Beijing Medical University

1993.12~1995.12  Postdoctoral fellow, School of Pharmaceutical Sciences, Beijing Medical University

1988.8~1993.12  Lecturer and Associate professor, Department of Chemistry, Zhengzhou University;

1982.1~1985.8   Teacher, Department of Chemistry, Henan University

1997.11~1998.3  Advanced Visiting Scholar, Pharmaceutical Institute, Bonn University, Germany.

2002.1~2002.9,  Visiting professor, Medinox. Inc., USA  

Teaching courses: Advanced Organic Synthesis, Heterocyclic Chemistry

Research interest: Study on the synthesis and biological function of heterocyclic compounds; Organic synthetic methodology;

Representative Publications since 2003:

1.      Junfeng Wang, Qin Li , Chao Qi, Yi Liu, Zemei Ge,* and Runtao Li *, Primary 1,2-diamine catalysis III: An unexpected domino reaction for the synthesis of multisubstituted cyclohexa-1,3-dienamines, Org. Biomol. Chem., 2010, 8, 4240 - 4242

1.      Junfeng Wang, Xin Wang, Zemei Ge,* Tieming Cheng, Runtao Li.* Highly enantioselective Michael addition of cyclopentanone with chalcones via novel di-iminium mechanism. Chem. Commun., 2010, 46, 1751-1753.

2.      Junfeng Wang, Chao Qi, Zemei Ge,* Tieming Cheng, Runtao Li.* Efficient direct asymmetric vinylogous Michael addition reactions of g-butenolides to chalcones catalyzed by vicinal primary-diamine salts. Chem. Commun., 2010, 46, 2124-2126.

3.      Xin Ai, Xin Wang*, Jin-ming Liu, Ze-mei Ge, Tie-ming Cheng, Run-tao Li^* An effective Aza-Michael addition of aromatic amines to electron-de？cient alkenes in alkaline Al₂O_3. Tetrahedron, 2010, 66 (29), 5373-5377.

4.      Fang-bin Han, Ze-mei Ge, Tie-ming Cheng, Run-tao Li*. Novel One-Pot, Four-Component Synthesis of 3-Alkyldithiocarbonyl-oxazolidines from Aminoethanols, Ketones, Carbon Disulfide, and Halides. Synlett, 2009, 4, 648-650.

5.      Shuai Xia , Xin Wang,* Ze-mei Ge, Tie-ming Cheng, Run-tao Li*. An ef？cient synthesis of aryldithiocarbamic acid esters from Michael addition of electron-de？cient alkenes with arylamines and CS2 in solid media alkaline Al₂O_3, Tetrahedron, 2009, 65, 1005-1009.

6.      Jun-feng Wang, Meng Lei , Qin Li , Ze-mei Ge, Xin Wang, Run-tao Li*. A novel and ef？cient direct aldol condensation from ketones and aromatic aldehydes catalyzed by proline–TEA through a new pathway. Tetrahedron, 2009, 65, 4826-4833.

7.      Zhong-qing Wang, Ze-mei Ge, Tie-ming Cheng, Run-tao Li*. Synthesis of Highly Substituted Pyridines via a One-Pot, Three-Component Cascade Reaction of Malononitrile with Aldehydes and S-Alkylisothiouronium Salts in Water. Synlett, 2009, 4, 648-650.

8.      Yongqiang Zhu, Shuyang Yao , Bo Xu, Zemei Ge, Jingrong Cui, Tieming Cheng, Runtao Li. Design, synthesis and biological evaluation of tripeptide boronic acid proteasome inhibitors. Bioorg. Med. Chem. 2009, 17, 6851-6861.

9.      Qi Sun, Cai-Qin Yue,a Jia Ye, Chang-Ling Li, Tie-Ming Cheng, Run-Tao Li*. Unique spirocyclopiperazinium salt III: Further investigation of monospirocyclo- piperazinium (MSPZ) salts as potential analgesics. Bioorg. Med. Chem. Lett., 2007, 17, 6245-6249.

10.   Song-wen Lin, Qi Sun, Run-tao Li.* Tie-ming Cheng, Ze-mei Ge*, Potassium Phosphate Promoted Aza-Markovnikov Addition of N-Heterocycles to Vinyl Esters. Synthesis, 2007, 13, 1933-1938.

11.   Yan Zhao, Ze-Mei Ge, Tie-Ming Cheng, Run-Tao Li*, Thia-Michael Addition Using Cheap and Odorless S-Alkylisothiouronium Salts as Thiol Equivalents in Water. Synlett, 2007, 10, 1529-1532.

12.   Meng Lei , Lanxiang Shi, Gong Li, Shilv Chen, Weihai Fang, Zemei Ge, Tieming Cheng, Runtao Li *, Dipeptide-catalyzed direct asymmetric aldol reactions in the presence of water. Tetrahedron, 2007, 63, 7892-7898.

13.   Ang Li, Xin Wang, Cai-Qin Yue, Jia Ye, Chang-Ling Li, Run-Tao Li*. Unique spirocyclopiperazinium salt. Part 4: Modification of dispirocyclo- piperazinium (DSPZ) salts as analgesics，Bioorg. Med. Chem. Lett., 2007, 17, 5078-5081.

14.   Xueling Hou , Zemei Ge, Tingmin Wang , Wei Guo, Jingrong Cui, Tieming Cheng, Chingshan Lai, Runtao Li *. Dithiocarbamic acid esters as anticancer agent. Part 1: 4-Substituted-piperazine-1-carbodithioic acid 3-cyano-3,3-diphenyl-propyl esters, Bioorg. Med. Chem. Lett., 2006, 16, 4214-4219.

15.   Chuan-Xin Zhang, Yi-Qiang Wang, Yong-Sheng Duan, Ze-Mei Ge, Tie-Ming Cheng, Run-Tao Li,* Selective Michael addition of pyrrole to conjugated alkenes catalyzed by Cr³⁺-Catsan and ZnCl₂, Catalysis Communications, 2006, 7, 534-537.

16.   Wang, Xin; Sha, Yaowu; Hou, Xueling; Li, Runtao*, Electrospray ionization tandem mass spectrometric analysis of fragmentation patterns of dithiocarbamate derivatives. Rapid Commun. Mass Spectrom., 2006, 20(4), 719-722.

17.   Zhang, Chuan-Xin; Ge, Ze-Mei; Cheng, Tie-Ming; Li, Run-Tao*. Synthesis and analgesic activity of secondary amine analogues of pyridylmethylamine and positional isomeric analogues of ABT-594. Bioorg. Med. Chem. Lett., 2006, 16, 2013-2016.

18.   Zhu, Yong-Qiang; Pei, Jian-Feng; Liu, Zhen-Ming; Lai, Lu-Hua; Cui, Jing-Rong; Li, Run-Tao*. 3D-QSAR studies on tripeptide aldehyde inhibitors of proteasome using CoMFA and CoMSIA methods. Bioorg. Med. Chem. 2006, 14(5), 1483-1496..

19.   Qi Sun, Run-Tao Li, Wei Guo, Jing-Rong Cui, Tie-Ming Cheng and Ze-Mei Ge,* Novel class of cyclophosphamide prodrug: Cyclophosphamide spiropiperaziniums (CPSP), Bioorg. Med. Chem. Lett., 2006, 16, 3727-3730.